Truong Lab 

Human macroH2A1 drives nucleosome dephasing and genome instability in histone-humanized yeast.

Haase MAB, Lazar-Stefanita L, Ólafsson G, Wudzinska A, Shen MJ, Truong DM, Boeke JD. (2024). Cell Reports.

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Writing the dark matter of the human genome into mice to better model human disease.
Truong DM. (2024). Synthetic Biology.

An artificial protein translation language makes bacteria resistant to viruses.

Truong DM. (2023). Synthetic Biology.​

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DASH/Dam1 complex mutants stabilize ploidy in histone-humanized yeast by weakening kinetochore-microtubule attachments.

Haase MAB, Ólafsson G, Flores RL, Boakye-Ansah E, Zelter A, Dickinson MS, Lazar-Stefanita L, DM Truong, Asbury CL, Davis TN, Boeke JD. (2022). EMBO Journal.

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Mouse chromosomes get supersized but find their limits.

DM Truong. (2022). Synthetic Biology.

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A versatile platform for locus-scale genome rewriting and verification.

R Brosh, JM Laurent, R Ordoñez, E Huang, MS Hogan, AM Hitchcock, LA Mitchell, S Pinglay, J Cadley, RD Luther, DM Truong, JD Boeke, MT Maurano. (2021). PNAS.

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Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation.

MI Valencia-Sánchez, P De Ioannes, M Wang, DM Truong, R Lee, JP Armache, JD Boeke, KJ Armache. (2021). Science.

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Comprehensive scanning mutagenesis of human retrotransposon LINE-1 identifies motifs essential for function.

EM Adney, MT Ochmann, S Sil, DM Truong, P Mita, X Wang, DJ Kahler, D Fenyo, LJ Holt, JD Boeke. (2019). Genetics.

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Superloser: A Plasmid Shuffling Vector for Saccharomyces cerevisiae with Exceedingly Low Background.

MAB Haase, DM Truong, JD Boeke. (2019). G3.

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Resetting the yeast epigenome with human nucleosomes.

DM Truong, JD Boeke. (2017). Cell.

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Retrohoming of a mobile group II intron in human cells suggests how eukaryotes limit group II intron proliferation.

DM Truong, FC Hewitt, JH Hanson, X Cui, AM Lambowitz. (2015). PLOS Genetics.

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Versatile genetic assembly system (VEGAS) to assemble pathways for expression in S. cerevisiae.

LA Mitchell, J Chuang, N Agmon, C Khunsriraksakul, NA Phillips, Y Cai, DM Truong, A Veerakumar, Y Wang, M Mayorga, P Blomquist, P Sadda, Trueheart J, JD Boeke. (2015). Nucleic Acids Res.

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Enhanced group II intron retrohoming in magnesium-deficient Escherichia coli via selection of mutations in the ribozyme core.

DM Truong, DJ Sidote, R Russell, AM Lambowitz. (2013). PNAS.

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Genetic and biochemical assays reveal a key role for replication restart proteins in group II intron retrohoming.

J Yao, DM Truong, AM Lambowitz. (2013). PLOS Genetics.

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Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling.

MA Nagle, DM Truong, AV Dnyanmote, SY Ahn, SA Eraly, W Wu, SK Nigam. (2011). J Biol Chem.

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β1-Integrin is required for kidney collecting duct morphogenesis and maintenance of renal function.

W Wu, S Kitamura, DM Truong, T Rieg, V Vallon, H Sakurai, KT Bush, DR Vera, RS Ross, SK Nigam. (2009). AJP Renal Phys.

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Organic anion transporter 3 contributes to the regulation of blood pressure.

V Vallon, SA Eraly, WR Wikoff, T Rieg, G Kaler, DM Truong, SY Ahn, NR Mahapatra, SK Mahata, JA Gangoiti, W Wu, BA Barshop, G Siuzdak, SK Nigam. (2008). JASN.

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Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination.

DM Truong, G Kaler, A Khandelwal, PW Swaan, SK Nigam. (2007). J Biol Chem.

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Structural variation governs substrate specificity for organic anion transporter (OAT) homologs: potential remote sensing by OAT family members.

G Kaler, DM Truong, A Khandelwal, M Nagle, SA Eraly, PW Swaan, SK Nigam. (2007). J Biol Chem.

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Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions.

G Kaler, DM Truong, DE Sweeney, DW Logan, M Nagle, W Wu, SA Eraly, SK Nigam. (2006). BBRC.

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Analyses of 5′ regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3).

V Bhatnagar, G Xu, BA Hamilton, DM Truong, SA Eraly, W Wu, SK Nigam. (2006). J Hum Gen.

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Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.

SA Eraly, V Vallon, DA Vaughn, JA Gangoiti, K Richter, M Nagle, JC Monte, T Rieg, DM Truong, JM Long, BA Barshop, G Kaler, SK Nigam. (2006). J Biol Chem.